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Reduced ovarian reserve in patients with adult polymyositis.
- Source :
-
Clinical rheumatology [Clin Rheumatol] 2015 Oct; Vol. 34 (10), pp. 1795-9. Date of Electronic Publication: 2015 Sep 07. - Publication Year :
- 2015
-
Abstract
- Polymyositis (PM) affects female gender during reproductive age; however, there is no study assessing ovarian reserve in these patients to evaluate ovarian reserve markers in PM. Eight female patients with PM (Bohan and Peter criteria, 1975) with aged 18-40 years, followed at our tertiary centre from March 2011 to May 2014, were invited to participate. They were age-matched with 16 healthy individuals (control group). All were evaluated at early follicular phase of menstrual cycle. Follicle stimulating hormone (FSH), estradiol, inhibin B, anti-Müllerian hormone (AMH) serum levels (ELISA) and sonographic antral follicle count (AFC) were determined. PM patients and controls had comparable mean age (31.4 ± 6.5 vs. 30.7 ± 6.2 years, P = 0.946), ethnicity and socioeconomic class (P > 0.05). PM mean age of onset was 27.3 ± 6.5 years and disease duration of 6.5 ± 4.1 years. Menstrual cycles were alike in both groups with a similar frequency of age at menarche, gynaecological age, duration and length of menstrual cycle (P > 0.05). The median serum level of AMH was significantly lower in PM compared to controls [0.7(0.3-3.4) vs. 3.1(1.4-4.0), P = 0.021]. AMH levels ≤1 ng/mL (50 vs. 6.3 %, P = 0.024) and very low AFC (37.5 vs. 6.3 %, P = 0.037) were significantly in PM patients versus controls. The other hormones (FSH, inhibin B and estradiol levels) were similar between both groups (P > 0.05). The present study was the first to identify subclinical ovarian dysfunction in PM patients during reproductive ages. Further study is necessary to assess the possible role of PM-related factors that may influence the ovarian function of these patients.
- Subjects :
- Adolescent
Adult
Anti-Mullerian Hormone blood
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Estradiol blood
Female
Follicle Stimulating Hormone blood
Follicular Phase
Humans
Inflammation
Inhibins blood
Muscular Diseases complications
Muscular Diseases pathology
Ovarian Diseases complications
Ovarian Diseases pathology
Ovarian Follicle cytology
Social Class
Young Adult
Ovarian Reserve
Polymyositis complications
Subjects
Details
- Language :
- English
- ISSN :
- 1434-9949
- Volume :
- 34
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Clinical rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 26345632
- Full Text :
- https://doi.org/10.1007/s10067-015-3064-1