CD36 deficiency blunts effects of diet on regulatory T cells in murine gonadal adipose tissue and mesenteric lymph nodes.

Authors :: Geys L
Vranckx C
Lijnen HR
Scroyen I
Source :: Cellular immunology [Cell Immunol] 2015 Nov-Dec; Vol. 298 (1-2), pp. 33-6. Date of Electronic Publication: 2015 Sep 01.
Publication Year :: 2015
Abstract: The effect of cluster of differentiation (CD)36 on regulatory T cells (Treg) was investigated in gonadal (GN) adipose tissues and mesenteric lymph nodes (MLN) of wild-type (WT) and CD36 deficient (CD36(-/-)) mice kept on standard fat (SFD, lean) or on high fat diet (HFD, obese). GN adipose tissue mass was smaller, but MLN size larger for obese CD36(-/-) versus obese WT mice. Overall, the reduction of Treg cells in GN adipose tissue and MLN after a HFD is much more prominent in WT than CD36(-/-) mice. Moreover, CD36(-/-) mice may be protected against obesity-related chronic inflammation.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)

Subjects :: Adipose Tissue cytology
Animals
CD36 Antigens deficiency
Diet, High-Fat
Gonads cytology
Inflammation genetics
Inflammation immunology
Lymph Nodes cytology
Male
Mesentery cytology
Mice
Mice, Inbred C57BL
Mice, Knockout
CD36 Antigens genetics
Lymph Nodes immunology
Mesentery immunology
Obesity immunology
T-Lymphocytes, Regulatory immunology

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