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BTK Signaling in B Cell Differentiation and Autoimmunity.
- Source :
-
Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2016; Vol. 393, pp. 67-105. - Publication Year :
- 2016
-
Abstract
- Since the original identification of Bruton's tyrosine kinase (BTK) as the gene defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on the physiological function of BTK has expanded impressively. In this review, we focus on the role of BTK during B cell differentiation in vivo, both in the regulation of expansion and in the developmental progression of pre-B cells in the bone marrow and as a crucial signal transducer of signals downstream of the IgM or IgG B cell antigen receptor (BCR) in mature B cells governing proliferation, survival, and differentiation. In particular, we highlight BTK function in B cells in the context of host defense and autoimmunity. Small-molecule inhibitors of BTK have very recently shown impressive anti-tumor activity in clinical studies in patients with various B cell malignancies. Since promising effects of BTK inhibition were also seen in experimental animal models for lupus and rheumatoid arthritis, BTK may be a good target for controlling autoreactive B cells in patients with systemic autoimmune disease.
- Subjects :
- Agammaglobulinaemia Tyrosine Kinase
Agammaglobulinemia genetics
Agammaglobulinemia immunology
Agammaglobulinemia physiopathology
Animals
B-Lymphocytes cytology
B-Lymphocytes immunology
Genetic Diseases, X-Linked genetics
Genetic Diseases, X-Linked immunology
Genetic Diseases, X-Linked physiopathology
Humans
Protein-Tyrosine Kinases genetics
Signal Transduction
Agammaglobulinemia enzymology
Autoimmunity
B-Lymphocytes enzymology
Cell Differentiation
Genetic Diseases, X-Linked enzymology
Protein-Tyrosine Kinases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0070-217X
- Volume :
- 393
- Database :
- MEDLINE
- Journal :
- Current topics in microbiology and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26341110
- Full Text :
- https://doi.org/10.1007/82_2015_478