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The Pharmacokinetic Profile of a New Gastroresistant Capsule Preparation of Eicosapentaenoic Acid as the Free Fatty Acid.
- Source :
-
BioMed research international [Biomed Res Int] 2015; Vol. 2015, pp. 360825. Date of Electronic Publication: 2015 Aug 03. - Publication Year :
- 2015
-
Abstract
- Supplementation with n-3 polyunsaturated fatty acids (n-3 PUFAs) may be beneficial for patients with inflammatory bowel diseases (IBD). In this study we analyzed the pharmacokinetic profile of eicosapentaenoic acid (EPA), as the free fatty acid (FFA), in an enteric-coated preparation, in 10 ulcerative colitis (UC) and 10 Crohn's disease (CD) patients and 15 healthy volunteers (HV). Subjects received 2 g daily of EPA-FFA for 8 weeks. Plasma phospholipid and red blood cell (RBC) membrane fatty acid content were measured by gas chromatography-mass spectrometry. There was a rapid incorporation of EPA into plasma phospholipids by 2 weeks and a slower, but highly consistent, incorporation into RBC membranes (4% total fatty acid content; coefficient of variation 10-16%). There was a concomitant reduction in relative n-6 PUFA content. Elongation and desaturation of EPA into docosahexaenoic acid (DHA) via docosapentaenoic acid (DPA) were apparent and DHA content also increased in membranes. EPA-FFA is well tolerated and no difference in the pharmacokinetic profile of n-3 PUFA incorporation was detected between IBD patients and HV. Our data support the concept that EPA can be considered the "universal donor" with respect to key n-3 PUFAs and that this enteric-coated formulation allows long term treatment with a high level of compliance.
- Subjects :
- Adult
Chemistry, Pharmaceutical
Colitis, Ulcerative blood
Colitis, Ulcerative pathology
Crohn Disease blood
Crohn Disease pathology
Dietary Supplements
Docosahexaenoic Acids administration & dosage
Eicosapentaenoic Acid chemistry
Female
Fish Oils administration & dosage
Healthy Volunteers
Humans
Male
Middle Aged
Triglycerides blood
Colitis, Ulcerative diet therapy
Crohn Disease diet therapy
Eicosapentaenoic Acid administration & dosage
Fatty Acids, Omega-3 blood
Subjects
Details
- Language :
- English
- ISSN :
- 2314-6141
- Volume :
- 2015
- Database :
- MEDLINE
- Journal :
- BioMed research international
- Publication Type :
- Academic Journal
- Accession number :
- 26339608
- Full Text :
- https://doi.org/10.1155/2015/360825