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Emerging trends in enzyme inhibition by multivalent nanoconstructs.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2015 Oct 21; Vol. 13 (39), pp. 9894-906. - Publication Year :
- 2015
-
Abstract
- Multivalent nanoconstructs, extensively used for enhancing the recognition of biomolecular targets, have been recently exploited for enzyme inhibition showing interesting properties such as improvement of inhibitory potency and selectivity. We review herein the recent results highlighting the potential of multivalent nanoconstructs for the inhibition of different enzymes, and the emerging trends in the generation and identification of multivalent clusters as enzyme inhibitors.
- Subjects :
- Animals
Carbonic Anhydrase Inhibitors chemistry
Carbonic Anhydrase Inhibitors pharmacology
Carbonic Anhydrases chemistry
Carbonic Anhydrases metabolism
Glycoside Hydrolases antagonists & inhibitors
Glycoside Hydrolases chemistry
Glycoside Hydrolases metabolism
Humans
Models, Molecular
Drug Discovery methods
Enzyme Inhibitors chemistry
Enzyme Inhibitors pharmacology
Nanostructures chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 13
- Issue :
- 39
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26338715
- Full Text :
- https://doi.org/10.1039/c5ob01405k