Improving the performance of J-modulated ADEQUATE experiments through homonuclear decoupling and non-uniform sampling.

Homonuclear ¹³ C- ¹³ C couplings at natural abundance can be measured using the J-modulated Adequate DoublE QUAntumTransfer Experiment (ADEQUATE) experiment. To somewhat ameliorate F ₁ digitization requirements, a scaling factor was incorporated into the original pulse sequence. Non-uniform sampling provides an obvious avenue to further facilitate the acquisition of ¹ J _CC and ⁿ J _CC homonuclear coupling constant data. We introduce homonuclear decoupling (HD) analogous to that described for the 1,1-HD-ADEQUATE and 1,n-HD-ADEQUATE experiments and evaluate the combination of non-uniform sampling and HD on the acquisition of both ¹ J _CC and ⁿ J _CC homonuclear ¹³ C- ¹³ C coupling constants using ibuprofen as a model compound. Copyright © 2015 John Wiley & Sons, Ltd.
(Copyright © 2015 John Wiley & Sons, Ltd.)