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Cluster analysis of Scedosporium boydii infections in a single hospital.
- Source :
-
International journal of medical microbiology : IJMM [Int J Med Microbiol] 2015 Oct; Vol. 305 (7), pp. 724-8. Date of Electronic Publication: 2015 Aug 24. - Publication Year :
- 2015
-
Abstract
- Scedosporiosis is a rare, but often fatal mycotic infection occurring in immunosuppressed as well as in immunocompetent patients. Over a period of 14 months, Scedosporium boydii isolates were sent to our reference laboratory from six immunocompetent patients treated at a single hospital in Germany. In analogy to the EORTC/MSG criteria, four patients were classified as proven invasive scedosporiosis cases, and two patients as probable or possible cases. Of note, in five patients scedosporiosis was diagnosed between 1 and 14 months (median 5.0 months) after cardiac surgery. Despite antimycotic treatment two patients died, and three were lost for long-term follow-up. All clinical S. boydii isolates were characterized by molecular analysis using multilocus sequence typing (MLST). An identical MLST type was found in five patients who had been treated in the surgery unit, suggesting a link between these infections. The source of S. boydii has not been identified. Within an observation period of 2 years before and after this cluster of infections no further cases of scedosporiosis were reported from this hospital.<br /> (Copyright © 2015 Elsevier GmbH. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Antifungal Agents therapeutic use
Child
Cross Infection drug therapy
Cross Infection microbiology
Female
Genotype
Germany epidemiology
Hospitals
Humans
Male
Middle Aged
Molecular Epidemiology
Multilocus Sequence Typing
Mycoses drug therapy
Mycoses microbiology
Scedosporium isolation & purification
Survival Analysis
Young Adult
Cluster Analysis
Cross Infection epidemiology
Mycoses epidemiology
Scedosporium classification
Scedosporium genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0607
- Volume :
- 305
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- International journal of medical microbiology : IJMM
- Publication Type :
- Academic Journal
- Accession number :
- 26330287
- Full Text :
- https://doi.org/10.1016/j.ijmm.2015.08.024