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Laparoscopic donor nephrectomy for the pediatric recipient population: Risk factors for adverse outcomes.
- Source :
-
Pediatric transplantation [Pediatr Transplant] 2015 Dec; Vol. 19 (8), pp. 836-43. Date of Electronic Publication: 2015 Aug 29. - Publication Year :
- 2015
-
Abstract
- Kidney transplantation is the optimal treatment of ESRD in children. Some studies have reported inferior outcomes in recipients of LDN allografts who are ≤ 5 yr of age. We performed a retrospective review of pediatric recipient outcomes of 110 LDN allografts at our institution and examined predictors of adverse outcomes. Subgroup analysis was performed by dividing recipients into three age categories: 0-5 yr, 6-17 yr, and ≥ 18 yr. There was no significant difference between incidences of DGF or ARE between groups. Kaplan-Meier analysis demonstrated 100% allograft survival in 0- to 5-yr-old recipients, nearly reaching statistical significance (p = 0.07) for outcome superior to that of the two older age groups. Pretransplant HD was associated with increased risk of DGF (p = 0.05). Significant risk factors for ARE were recipient weight >15 kg (p = 0.033) and multiple renal arteries (p = 0.047). Previous ARE was associated with an increased risk of allograft failure (p = 0.02). LDN is not associated with increased risk of DGF, ARE, or allograft failure in the youngest recipients. These findings support an aggressive pursuit of preemptive transplantation even in the youngest pediatric allograft recipients.<br /> (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Age Factors
Child
Child, Preschool
Delayed Graft Function etiology
Female
Follow-Up Studies
Graft Rejection etiology
Graft Survival
Humans
Infant
Infant, Newborn
Kaplan-Meier Estimate
Male
Retrospective Studies
Risk Factors
Transplantation, Homologous
Treatment Outcome
Young Adult
Kidney Failure, Chronic surgery
Kidney Transplantation
Laparoscopy
Living Donors
Nephrectomy methods
Tissue and Organ Harvesting methods
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3046
- Volume :
- 19
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Pediatric transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 26329665
- Full Text :
- https://doi.org/10.1111/petr.12587