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"Let there be light": the role of vitamin D in the immune response to vaccines.
- Source :
-
Expert review of vaccines [Expert Rev Vaccines] 2015; Vol. 14 (11), pp. 1427-40. Date of Electronic Publication: 2015 Aug 31. - Publication Year :
- 2015
-
Abstract
- Vitamin D's non-skeletal actions, including immunomodulatory role, have been increasingly recognized. Of significance, many immune cells are able to synthesize a biologically active form of vitamin D from circulating 25-hydroxyvitamin D with subsequent intracrine actions, and the vitamin D receptor is broadly distributed. In this review, we discuss vitamin D's potent role in innate and adaptive immune responses and published studies evaluating the impact of serum vitamin D, vitamin D gene pathway polymorphisms or empiric vitamin D supplementation on vaccine immunogenicity. We highlight existing knowledge gaps and propose the steps needed to advance the science and answer the question of whether vitamin D may prove valuable as a vaccine adjuvant for certain vaccines against infectious diseases.
Details
- Language :
- English
- ISSN :
- 1744-8395
- Volume :
- 14
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Expert review of vaccines
- Publication Type :
- Academic Journal
- Accession number :
- 26325349
- Full Text :
- https://doi.org/10.1586/14760584.2015.1082426