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Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
- Source :
-
Developmental cell [Dev Cell] 2015 Sep 14; Vol. 34 (5), pp. 493-504. Date of Electronic Publication: 2015 Aug 27. - Publication Year :
- 2015
-
Abstract
- Postnatal organogenesis occurs in an immune competent environment and is tightly controlled by interplay between positive and negative regulators. Innate immune cells have beneficial roles in postnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored. Here we show that adaptive immune responses participate in the normal postnatal development of a non-lymphoid epithelial tissue. Since the mammary gland (MG) is the only organ developing predominantly after birth, we utilized it as a powerful system to study adaptive immune regulation of organogenesis. We found that antigen-mediated interactions between mammary antigen-presenting cells and interferon-γ (IFNγ)-producing CD4+ T helper 1 cells participate in MG postnatal organogenesis as negative regulators, locally orchestrating epithelial rearrangement. IFNγ then affects luminal lineage differentiation. This function of adaptive immune responses, regulating normal development, changes the paradigm for studying players of postnatal organogenesis and provides insights into immune surveillance and cancer transformation.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Antigen-Presenting Cells cytology
Breast growth & development
Breast metabolism
Epithelial Cells immunology
Epithelium immunology
Female
Humans
Immunity, Innate immunology
Interferon-gamma metabolism
Mice
Adaptive Immunity immunology
Antigen-Presenting Cells immunology
Breast immunology
Epithelial Cells cytology
Epithelium metabolism
Organogenesis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1551
- Volume :
- 34
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Developmental cell
- Publication Type :
- Academic Journal
- Accession number :
- 26321127
- Full Text :
- https://doi.org/10.1016/j.devcel.2015.07.015