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[Occurrence, intratumoral heterogeneity, prognostic and predictive potential of microsatellite instability following surgical resection of primary colorectal carcinomas and corresponding liver metastases].
- Source :
-
Orvosi hetilap [Orv Hetil] 2015 Sep 06; Vol. 156 (36), pp. 1460-71. - Publication Year :
- 2015
-
Abstract
- Introduction: Besides clinicopathological parameters, molecular markers can be very important, and further characterize colorectal carcinomas into chromosomally unstable, microsatellite instable and "CqG-island methylator phenotype" groups.<br />Aim: To study the frequency of microsatellite instability using immunohistochemical evaluation of MLH1, MSH2, MSH6 and PMS2 proteins in colorectal carcinoma.<br />Method: 122 colorectal carcinomas as well as in 69 paired liver metastases were evaluated. Additionally, prognostic and predictive potential of mismatch repair status was tested.<br />Results: Microsatellite instable phenotype was identified in 11.5% (14/122) of the tumours. There were no differences regarding staining intensity of tumour regions. Mismatch repair status was discordant in primaries vs. metastases in 20.2%. There was no difference in progression free- and overall survival according to mismatch repair status. The mismatch repair status was not predictive for survival within systemic therapy regimen groups.<br />Conclusions: The subgroups of colorectal carcinomas could be evaluated in a larger and homogenised patient cohort to predict prognosis and response to therapy.
- Subjects :
- Adult
Aged
Antibodies, Monoclonal administration & dosage
Bevacizumab administration & dosage
Camptothecin administration & dosage
Camptothecin analogs & derivatives
Cetuximab administration & dosage
Colorectal Neoplasms drug therapy
Colorectal Neoplasms pathology
Disease-Free Survival
Female
Fluorouracil administration & dosage
Humans
Irinotecan
Liver Neoplasms drug therapy
Liver Neoplasms genetics
Liver Neoplasms metabolism
Male
Middle Aged
Neoplasm Staging
Organoplatinum Compounds administration & dosage
Oxaliplatin
Panitumumab
Predictive Value of Tests
Prognosis
Survival Analysis
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Biomarkers, Tumor analysis
Colorectal Neoplasms genetics
Colorectal Neoplasms surgery
DNA Mismatch Repair
Genetic Markers
Liver Neoplasms surgery
Microsatellite Instability
Subjects
Details
- Language :
- Hungarian
- ISSN :
- 0030-6002
- Volume :
- 156
- Issue :
- 36
- Database :
- MEDLINE
- Journal :
- Orvosi hetilap
- Publication Type :
- Academic Journal
- Accession number :
- 26320600
- Full Text :
- https://doi.org/10.1556/650.2015.30218