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NUTRITIONAL, MICROBIOLOGICAL, AND THERAPEUTIC FACTORS RELATED TO MUCOSITIS IN HEAD AND NECK CANCER PATIENTS: A COHORT STUDY.
- Source :
-
Nutricion hospitalaria [Nutr Hosp] 2015 Sep 01; Vol. 32 (3), pp. 1208-13. Date of Electronic Publication: 2015 Sep 01. - Publication Year :
- 2015
-
Abstract
- Purpose: the objective was to demonstrate if treatment modality, nutritional status and oropharyngeal flora contribute to the development of mucositis in radiotherapy- treated head and neck cancer.<br />Methods: single-cohort study of patients with head and neck cancer (H&N) in which radiotherapy was indicated. Nutritional status was evaluated using SGA, BMI, and FFMI. A buccal smear was performed before radiotherapy for cultivation of bacteria and yeasts. Mucositis was evaluated using the WHO grades. Relative risk (RR) and its 95% CI were calculated.<br />Results: the study included 35 patients, 74.3% males, 63.8 (9.9) years of age, and 34.3% malnourished. The diagnoses included larynx (40.0%), oral (25.7%), and pharynx cancer (11.4%). Treatment comprised 66.0 Gy of radiation, chemotherapy (60.0%), and surgery (57.1%). Bacteria were found in 28.6%, including Staphylococcus aureus (8.6%) and Escherichia coli (8.6%). Yeasts (Candida spp.) were found in 35.3%. Mucositis was more frequent in patients with definitive radiotherapy [100% vs. 65%, p = 0.01; RR = 1.54 (CI95% 1.12 to 2.12)]. Neither SGA nor BMI or FFMI were related to the development or severity of mucositis. Positive cultures for bacteria before radiotherapy were related to severe mucositis [44.4% vs. 12%, p = 0.039; RR = 4.17 (CI95% 1.22 to 14.24)], but there was no relationship with the presence of yeasts. Previous surgery was not associated with the appearance of the studied strains of bacteria.<br />Conclusion: bacterial colonization of the oropharynx prior to radiotherapy may be a factor for severe mucositis in H&N patients.<br /> (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)
- Subjects :
- Aged
Anthropometry
Cohort Studies
Combined Modality Therapy
Female
Head and Neck Neoplasms diagnosis
Head and Neck Neoplasms therapy
Humans
Male
Middle Aged
Neoplasm Staging
Oropharynx microbiology
Head and Neck Neoplasms complications
Microbiota
Mucositis diagnosis
Mucositis etiology
Nutritional Status
Subjects
Details
- Language :
- English
- ISSN :
- 1699-5198
- Volume :
- 32
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nutricion hospitalaria
- Publication Type :
- Academic Journal
- Accession number :
- 26319840
- Full Text :
- https://doi.org/10.3305/nh.2015.32.3.9299