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Medication Initiation Burden Required to Comply With Heart Failure Guideline Recommendations and Hospital Quality Measures.
- Source :
-
Circulation [Circulation] 2015 Oct 06; Vol. 132 (14), pp. 1347-53. Date of Electronic Publication: 2015 Aug 27. - Publication Year :
- 2015
-
Abstract
- Background: Guidelines for heart failure (HF) recommend prescription of guideline-directed medical therapy before hospital discharge; some of these therapies are included in publicly reported performance measures. The burden of new medications for individual patients has not been described.<br />Methods and Results: We used Get With The Guidelines-HF registry data from 2008 to 2013 to characterize prescribing, indications, and contraindications for angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, β-blockers, aldosterone antagonists, hydralazine/isosorbide dinitrate, and anticoagulants. The difference between a patient's medication regimen at hospital admission and that recommended by HF quality measures at discharge was calculated. Among 158 922 patients from 271 hospitals with a primary discharge diagnosis of HF, initiation of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers was indicated in 18.1% of all patients (55.5% of those eligible at discharge were not receiving angiotensin-converting enzyme inhibitors or angiotensin receptor blockers at admission), β-blockers in 20.3% (50.5% of eligible), aldosterone antagonists in 24.1% (87.4% of eligible), hydralazine/isosorbide dinitrate in 8.6% (93.1% of eligible), and anticoagulants in 18.0% (58.0% of eligible). Cumulatively, 0.4% of patients were eligible for 5 new medication groups, 4.1% for 4 new medication groups, 9.4% for 3 new medication groups, 10.1% for 2 new medication groups, and 22.7% for 1 new medication group; 15.0% were not eligible for new medications because of adequate prescribing at admission; and 38.4% were not eligible for any medications recommended by HF quality measures. Compared with newly indicated medications (mean, 1.45 ± 1.23), actual new prescriptions were lower (mean, 1.16 ± 1.00).<br />Conclusions: A quarter of patients hospitalized with HF need to start >1 medication to meet HF quality measures. Systems for addressing medication initiation and managing polypharmacy are central to HF transitional care.<br /> (© 2015 American Heart Association, Inc.)
- Subjects :
- Aged
Aged, 80 and over
Body Mass Index
Cardiovascular Agents classification
Comorbidity
Contraindications
Cross-Sectional Studies
Drug Hypersensitivity epidemiology
Drug Prescriptions statistics & numerical data
Drug Therapy, Combination
Drug Utilization
Evidence-Based Medicine
Female
Heart Failure classification
Heart Failure epidemiology
Humans
Male
Medication Adherence
Middle Aged
Patient Admission statistics & numerical data
Patient Discharge statistics & numerical data
Polypharmacy
Cardiovascular Agents therapeutic use
Drug Prescriptions standards
Drug Substitution statistics & numerical data
Guideline Adherence
Heart Failure drug therapy
Hospitals standards
Practice Guidelines as Topic
Quality Assurance, Health Care
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4539
- Volume :
- 132
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Circulation
- Publication Type :
- Academic Journal
- Accession number :
- 26316616
- Full Text :
- https://doi.org/10.1161/CIRCULATIONAHA.115.014281