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Whole Body MRI in the Staging of Esophageal Cancer--A Prospective Comparison with Whole Body 18F-FDG PET-CT.
- Source :
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Digestive surgery [Dig Surg] 2015; Vol. 32 (5), pp. 397-408. Date of Electronic Publication: 2015 Aug 26. - Publication Year :
- 2015
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Abstract
- Background: Positron emission tomography and computed tomography (PET-CT) is established in the staging of esophageal cancer. In this study, an MRI protocol was designed to emulate the anatomical (T1-weighed (T1W) and T2W imaging) and functional information (diffusion-weighted imaging) provided by PET-CT.<br />Methods: In all, 49 patients with carcinoma of the esophagus underwent PET-CT and whole-body MRI (WBMRI). WBMRI was carried out using dedicated sequences tailored to detect metastatic disease at each area corresponding to the anatomical coverage of PET-CT. Nodal status was determined from histopathology and endoscopic ultrasound biopsy (EUS).<br />Results: PET-CT and WBMRI identified the primary tumor in 46/49 (94%) and 48/49 (98%) patients, respectively. Nodal analysis in patients undergoing surgery (n = 18) yielded sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of 27, 100, 100, 47 and 56% for PET-CT, compared with 30, 100, 100, 53 and 61% for WBMRI. When nodal analysis included both surgical specimens and EUS criteria (n = 39), sensitivity, specificity, PPV, NPV and accuracy were 46, 91, 93, 40 and 59% for PET-CT compared with 59, 92, 94, 50 and 67% for WBMRI. Both imaging modalities identified distant metastases in 2 patients.<br />Conclusion: WBMRI has similar accuracy to PET-CT in detecting the primary tumor, nodal deposits and for exclusion of systemic metastatic disease.<br /> (© 2015 S. Karger AG, Basel.)
- Subjects :
- Adenocarcinoma diagnostic imaging
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell diagnostic imaging
Esophageal Neoplasms diagnostic imaging
Female
Fluorodeoxyglucose F18
Humans
Male
Middle Aged
Neoplasm Staging
Prospective Studies
Radiopharmaceuticals
Sensitivity and Specificity
Adenocarcinoma pathology
Carcinoma, Squamous Cell pathology
Esophageal Neoplasms pathology
Magnetic Resonance Imaging methods
Multimodal Imaging methods
Positron-Emission Tomography methods
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9883
- Volume :
- 32
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Digestive surgery
- Publication Type :
- Academic Journal
- Accession number :
- 26315570
- Full Text :
- https://doi.org/10.1159/000431292