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Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm.
- Source :
-
PloS one [PLoS One] 2015 Aug 26; Vol. 10 (8), pp. e0134386. Date of Electronic Publication: 2015 Aug 26 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- The aortic wall is perfused by the adventitial vasa vasorum (VV). Tissue hypoxia has previously been observed as a manifestation of enlarged abdominal aortic aneurysms (AAAs). We sought to determine whether hypoperfusion of the adventitial VV could develop AAAs. We created a novel animal model of adventitial VV hypoperfusion with a combination of a polyurethane catheter insertion and a suture ligation of the infrarenal abdominal aorta in rats. VV hypoperfusion caused tissue hypoxia and developed infrarenal AAA, which had similar morphological and pathological characteristics to human AAA. In human AAA tissue, the adventitial VV were stenotic in both small AAAs (30-49 mm in diameter) and in large AAAs (> 50 mm in diameter), with the sac tissue in these AAAs being ischemic and hypoxic. These results indicate that hypoperfusion of adventitial VV has critical effects on the development of infrarenal AAA.
- Subjects :
- Aged
Animals
Aorta, Abdominal metabolism
Aorta, Abdominal pathology
Aorta, Abdominal physiopathology
Aortic Aneurysm, Abdominal complications
Aortic Aneurysm, Abdominal metabolism
Aortic Aneurysm, Abdominal pathology
Constriction, Pathologic complications
Female
Humans
Male
Oxygen metabolism
Rats
Rats, Sprague-Dawley
Vasa Vasorum metabolism
Vasa Vasorum pathology
Aortic Aneurysm, Abdominal physiopathology
Blood Circulation
Vasa Vasorum physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 10
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 26308526
- Full Text :
- https://doi.org/10.1371/journal.pone.0134386