Patterns of Flavivirus Seroprevalence in the Human Population of Northern Laos.

Authors :: Conlan JV
Vongxay K
Khamlome B
Jarman RG
Gibbons RV
Fenwick SG
Thompson RCA
Blacksell SD
Source :: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2015 Nov; Vol. 93 (5), pp. 1010-1013. Date of Electronic Publication: 2015 Aug 24.
Publication Year :: 2015
Abstract: A total of 1,136 samples from 289 households in four provinces in northern Laos were subjected to Japanese encephalitis virus (JEV) and dengue virus hemagglutination inhibition (DENV HI). Overall, antibodies to JEV were detected by HI in 620 (54.6%) of 1,136 people; of which 217 (19.1%) had HI activity against JEV only. Antibodies to DENV4 were detected by HI in 526 (46.3%) of 1,136 people; of which 124 (10.9%) had HI activity against DENV4 only. Antibodies to DENV1-3 were detected by HI in 296 (26.1%), 274 (24.1%), and 283 (24.9) of 1,136 people, respectively; of which 7, 1, and 0, respectively, had HI activity against DENV1-3 only. JEV was the most prevalent Flavivirus in Oudomxay, Luangprabang, and Huaphan provinces and DENV4 was the most prevalent in Xiengkhouang province. Seroprevalence for JEV increased with increasing age and wealth and was higher in villages where rice was cultivated in paddy fields and highest for people of Lao-Tai ethnicity.<br /> (© The American Society of Tropical Medicine and Hygiene.)