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Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia.
- Source :
-
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2015 Sep 20; Vol. 33 (27), pp. 2949-62. Date of Electronic Publication: 2015 Aug 24. - Publication Year :
- 2015
-
Abstract
- Diagnosis, treatment, response monitoring, and outcome of pediatric acute myeloid leukemia (AML) have made enormous progress during the past decades. Because AML is a rare type of childhood cancer, with an incidence of approximately seven occurrences per 1 million children annually, national and international collaborative efforts have evolved. This overview describes these efforts and includes a summary of the history and contributions of each of the main collaborative pediatric AML groups worldwide. The focus is on translational and clinical research, which includes past, current, and future clinical trials. Separate sections concern acute promyelocytic leukemia, myeloid leukemia of Down syndrome, and relapsed AML. A plethora of novel antileukemic agents that have emerged, including new classes of drugs, are summarized as well. Finally, an important aspect of the treatment of pediatric AML--supportive care--and late effects are discussed. The future is bright, with a wide range of emerging innovative therapies and with more and more international collaboration that ultimately aim to cure all children with AML, with fewer adverse effects and without late effects.<br /> (© 2015 by American Society of Clinical Oncology.)
- Subjects :
- Adolescent
Adult
Age of Onset
Child
Child, Preschool
Cooperative Behavior
Diffusion of Innovation
Disease-Free Survival
History, 20th Century
History, 21st Century
Humans
Infant
Infant, Newborn
Leukemia, Myeloid, Acute diagnosis
Leukemia, Myeloid, Acute history
Leukemia, Myeloid, Acute mortality
Medical Oncology history
Pediatrics history
Risk Factors
Survivors
Time Factors
Treatment Outcome
Young Adult
Interdisciplinary Communication
International Cooperation
Leukemia, Myeloid, Acute therapy
Medical Oncology trends
Pediatrics trends
Subjects
Details
- Language :
- English
- ISSN :
- 1527-7755
- Volume :
- 33
- Issue :
- 27
- Database :
- MEDLINE
- Journal :
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 26304895
- Full Text :
- https://doi.org/10.1200/JCO.2015.62.8289