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Lineage distribution and E2 sequence variation of high-risk human papillomavirus types isolated from patients with cervical cancer in Sichuan province, China.
- Source :
-
Archives of virology [Arch Virol] 2015 Nov; Vol. 160 (11), pp. 2845-55. Date of Electronic Publication: 2015 Aug 26. - Publication Year :
- 2015
-
Abstract
- To explore the nucleotide sequence variability of the E2 gene in high-risk HPV types in cervical cancer patients from Sichuan province, China, the E2 genes of eight high-risk HPV types were amplified and sequenced. Several novel nucleotide substitutions and deletions were observed. The lineages to which the isolates belonged were determined by phylogenetic analysis, employing the sequence of the representative lineages/sublineages in the coherent classification and nomenclature system as references. This study updates the lineage distribution data on high-risk HPV types in Southwest China and helps broaden understanding of the polymorphism of the E2 gene.
- Subjects :
- Alphapapillomavirus chemistry
Alphapapillomavirus genetics
Amino Acid Sequence
China epidemiology
Female
Humans
Molecular Sequence Data
Oncogene Proteins, Viral chemistry
Papillomavirus Infections epidemiology
Phylogeny
Sequence Alignment
Uterine Cervical Neoplasms epidemiology
Alphapapillomavirus classification
Alphapapillomavirus isolation & purification
Genetic Variation
Oncogene Proteins, Viral genetics
Papillomavirus Infections virology
Uterine Cervical Neoplasms virology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-8798
- Volume :
- 160
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Archives of virology
- Publication Type :
- Academic Journal
- Accession number :
- 26303138
- Full Text :
- https://doi.org/10.1007/s00705-015-2559-z