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Colorectal adenoma is associated with coronary artery calcification in a Korean population.
Colorectal adenoma is associated with coronary artery calcification in a Korean population.
- Source :
-
Atherosclerosis [Atherosclerosis] 2015 Oct; Vol. 242 (2), pp. 515-20. Date of Electronic Publication: 2015 Aug 08. - Publication Year :
- 2015
-
Abstract
- Objective: Colorectal adenoma and coronary atherosclerosis have similar risk factors. The aim of this study was to investigate the association between colorectal adenoma and coronary artery calcification (CAC), which is used as a surrogate marker for coronary atherosclerosis.<br />Methods: This is a cross-sectional study of 398 Koreans (290 males, mean age of 56.8 ± 8.1 years) who underwent CAC scoring by multi-slice computed tomography and colonoscopy on the same day as the screening examination. The CAC scores were divided into the following three categories according to severity: absent (CAC score = 0), mild (0 < CAC score ≤ 100), and moderate-to-severe CAC (CAC score > 100).<br />Results: Colorectal adenoma was detected in 149 (37.4%) subjects and was significantly associated with a CAC score of >0 (OR = 1.66, 95% CI = 1.05-2.64, P = 0.032), including both mild (OR = 1.80, 95% CI = 1.06-3.03, P = 0.029) and moderate-to-severe CAC (OR = 1.95, 95% CI = 1.05-3.63, P = 0.035), in multivariate analysis after adjusting for age, gender and other risk factors. The proportion of subjects with colorectal adenoma and advanced adenoma progressively increased with increasing CAC score (colorectal adenoma 28.9%-54.1%, P for trend < 0.001; advanced adenoma 7.0%-16.4%, P for trend = 0.026).<br />Conclusion: Colorectal adenoma is related to coronary artery calcification independent of traditional risk factors for asymptomatic Koreans. The prevalence of advanced adenoma is more common in individuals with severe coronary atherosclerosis.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adenoma epidemiology
Adenoma ethnology
Aged
Calcinosis epidemiology
Calcinosis ethnology
Colonoscopy
Colorectal Neoplasms epidemiology
Colorectal Neoplasms ethnology
Coronary Artery Disease epidemiology
Coronary Artery Disease ethnology
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Multidetector Computed Tomography
Prevalence
Republic of Korea
Retrospective Studies
Risk Factors
Adenoma complications
Calcinosis complications
Colorectal Neoplasms complications
Coronary Artery Disease complications
Coronary Vessels physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 242
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 26298744
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2015.08.004