Back to Search
Start Over
The relationship between the severity of radiation-induced oral mucositis and the myeloperoxidase levels in rats.
- Source :
-
Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2015 Sep; Vol. 120 (3), pp. 329-36. Date of Electronic Publication: 2015 Apr 25. - Publication Year :
- 2015
-
Abstract
- Objective: Oral mucositis is a common adverse reaction to radiotherapy for head and neck cancer, and there are concerns regarding a decreased quality of life in patients receiving radiotherapy. The purpose of this study was to investigate the relationship between the severity of radiation-induced oral mucositis and the myeloperoxidase (MPO) levels in irradiated tissues.<br />Study Design: Ninety-six F344 rats were divided into the following 4 groups: 10-Gy, 18-Gy, and 30-Gy irradiation groups, and a nonirradiation group. Oral mucositis was induced by the administration of single doses of radiation via exposure. After irradiation, the rats were evaluated on the basis of weight measurements, macroscopic findings according to a grading scale (Oral Mucositis Index [OMI]), and the results of tissue MPO assays.<br />Results: Weights decreased whereas the OMI scores and MPO levels increased, depending on the dose of exposure. The Spearman rank correlation test showed a significant correlation between the OMI scores and the MPO levels in the tissues with a correlation coefficient of 0.824 (P < .01).<br />Conclusions: In this study, the MPO levels in the irradiated tissue were increased in the cases involving severe radiation-induced oral mucositis evaluated in rats using a grading scale.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Dose-Response Relationship, Radiation
Female
Head and Neck Neoplasms radiotherapy
Radiation Dosage
Rats
Rats, Inbred F344
Severity of Illness Index
Tongue radiation effects
Peroxidase metabolism
Radiation Injuries etiology
Radiation Injuries pathology
Stomatitis etiology
Stomatitis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2212-4411
- Volume :
- 120
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Oral surgery, oral medicine, oral pathology and oral radiology
- Publication Type :
- Academic Journal
- Accession number :
- 26297392
- Full Text :
- https://doi.org/10.1016/j.oooo.2015.04.012