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New associations of classic acute macular neuroretinopathy.
- Source :
-
The British journal of ophthalmology [Br J Ophthalmol] 2016 Mar; Vol. 100 (3), pp. 389-94. Date of Electronic Publication: 2015 Aug 20. - Publication Year :
- 2016
-
Abstract
- Purpose: To describe novel underlying associations of classic acute macular neuroretinopathy (AMN).<br />Methods: Multimodal imaging case series evaluating patients with classic AMN lesions and previously unreported underlying aetiologies.<br />Results: Six patients were included (five women, one man, mean age 30±7 years). Mean distance best corrected visual acuity at initial presentation was 0.21±0.3 logMAR (mean Snellen acuity: 20/30, range 20/15-20/100) and at last follow-up visit 0.09±0.17 logMAR (Snellen acuity: 20/20, range 20/15-20/60). All cases but one had bilateral lesions and showed typical parafoveal hyporeflective lesions on infrared imaging, which corresponded to the hyper-reflectivity in the Henle's layer with attenuation of the external limiting membrane, the ellipsoid zone and interdigitation zone. Underlying diseases included thrombocytopenia and anaemia associated with dengue fever, acute lymphoblastic leukaemia, chronic kidney disease and ulcerative colitis, while Valsalva-like manoeuvre was found to be a potential trigger. Other novel associations included the use of lisdexamphetamine.<br />Conclusions: Classic AMN may be associated with leukaemia, dengue fever, ulcerative colitis and chronic kidney disease, probably as a result of chorioretinal hypoxia in the setting of thrombocytopenia and anaemia. Adrenergic agonists such as lisdexamphetamine may also contribute to the manifestation of AMN.<br /> (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/)
- Subjects :
- Acute Disease
Adult
Anemia complications
Colitis, Ulcerative complications
Dengue complications
Female
Humans
Male
Multimodal Imaging
Precursor Cell Lymphoblastic Leukemia-Lymphoma complications
Renal Insufficiency, Chronic complications
Retrospective Studies
Thrombocytopenia complications
Tomography, Optical Coherence
Visual Acuity
Young Adult
Retinal Diseases diagnosis
Retinal Diseases etiology
Retinal Neurons pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2079
- Volume :
- 100
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The British journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 26294104
- Full Text :
- https://doi.org/10.1136/bjophthalmol-2015-306845