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Fibroblast growth factor receptor signaling in kidney and lower urinary tract development.
- Source :
-
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2016 Jun; Vol. 31 (6), pp. 885-95. Date of Electronic Publication: 2015 Aug 21. - Publication Year :
- 2016
-
Abstract
- Fibroblast growth factor receptors (FGFRs) and FGF ligands are highly expressed in the developing kidney and lower urinary tract. Several classic studies showed many effects of exogenous FGF ligands on embryonic renal tissues in vitro and in vivo. Another older landmark publication showed that mice with a dominant negative Fgfr fragment had severe renal dysplasia. Together, these studies revealed the importance of FGFR signaling in kidney and lower urinary tract development. With the advent of modern gene targeting techniques, including conditional knockout approaches, several publications have revealed critical roles for FGFR signaling in many lineages of the kidney and lower urinary tract at different stages of development. FGFR signaling has been shown to be critical for early metanephric mesenchymal patterning, Wolffian duct patterning including induction of the ureteric bud, ureteric bud branching morphogenesis, nephron progenitor survival and nephrogenesis, and bladder mesenchyme patterning. FGFRs pattern these tissues by interacting with many other growth factor signaling pathways. Moreover, the many genetic Fgfr and Fgf animal models have structural defects mimicking numerous congenital anomalies of the kidney and urinary tract seen in humans. Finally, many studies have shown how FGFR signaling is critical for kidney and lower urinary tract patterning in humans.
- Subjects :
- Acanthosis Nigricans genetics
Acanthosis Nigricans metabolism
Acrocephalosyndactylia genetics
Acrocephalosyndactylia metabolism
Animals
Antley-Bixler Syndrome Phenotype genetics
Antley-Bixler Syndrome Phenotype metabolism
Apoptosis
Craniosynostoses genetics
Craniosynostoses metabolism
Ear abnormalities
Gene Knockout Techniques methods
Humans
Kidney metabolism
Kidney pathology
Mice
Models, Animal
Mutation
Receptors, Fibroblast Growth Factor genetics
Scalp Dermatoses genetics
Scalp Dermatoses metabolism
Signal Transduction
Skin Abnormalities genetics
Skin Abnormalities metabolism
T-Box Domain Proteins genetics
Ureter metabolism
Ureter pathology
Urinary Bladder metabolism
Urinary Bladder pathology
Wolffian Ducts metabolism
Fibroblast Growth Factors metabolism
Kidney growth & development
Organogenesis genetics
Receptors, Fibroblast Growth Factor metabolism
Ureter growth & development
Urinary Bladder growth & development
Wolffian Ducts growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 1432-198X
- Volume :
- 31
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pediatric nephrology (Berlin, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 26293980
- Full Text :
- https://doi.org/10.1007/s00467-015-3151-1