Back to Search
Start Over
Relationships between serum asunaprevir concentration and alanine aminotransferase elevation during daclatasvir plus asunaprevir for chronic HCV genotype 1b infection.
- Source :
-
Journal of medical virology [J Med Virol] 2016 Mar; Vol. 88 (3), pp. 506-11. Date of Electronic Publication: 2015 Aug 27. - Publication Year :
- 2016
-
Abstract
- Alanine aminotransferase (ALT) elevations were the most frequent adverse events during all-oral combinations with daclatasvir and asunaprevir for patients with hepatitis C virus (HCV) infection, but the underline mechanisms are unclear. Seventy patients with chronic HCV genotype 1b infection, who were introduced daclatasvir 60 mg once daily plus asunaprevir 100 mg twice daily for 24 weeks, were measured serum asunaprevir concentrations at the one point or more of 2, 4, and 8 weeks after the start of treatment. In 4 and 8 weeks after the start of treatment, asunaprevir concentrations in patients with albumin levels <3.6 g/dl at baseline were significantly higher than those in patients with albumin levels ≥3.6 g/dl. The baseline factors did not affect to ALT severe elevations (≥300 IU/l). At 2 weeks after the start of treatment, ALT severe elevations with asunaprevir concentrations of ≥800 ng/ml (54.5%) tended to indicate the higher rates than those of <800 ng/ml (17.6%). Furthermore, the discontinuation or reduction of asunaprevir improved ALT levels, regardless the significant decrease of serum asunaprevir concentrations. In conclusion, serum albumin levels affected to serum asunaprevir concentrations, and serum asunaprevir concentrations might partly affect to ALT severe elevations. Further large-scale prospective studies are needed to investigate the impact of the discontinuation or reduction of asunaprevir to help in the design of more effective therapeutic regimens.<br /> (© 2015 Wiley Periodicals, Inc.)
- Subjects :
- Aged
Aged, 80 and over
Carbamates
Drug Therapy, Combination adverse effects
Female
Genotype
Hepacivirus drug effects
Hepatitis C, Chronic blood
Humans
Imidazoles adverse effects
Isoquinolines adverse effects
Male
Middle Aged
Pyrrolidines
Serum Albumin analysis
Sulfonamides adverse effects
Valine analogs & derivatives
Viral Load
Alanine Transaminase blood
Hepatitis C, Chronic drug therapy
Hepatitis C, Chronic virology
Imidazoles therapeutic use
Isoquinolines blood
Isoquinolines therapeutic use
Sulfonamides blood
Sulfonamides therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1096-9071
- Volume :
- 88
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of medical virology
- Publication Type :
- Academic Journal
- Accession number :
- 26292191
- Full Text :
- https://doi.org/10.1002/jmv.24360