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Bu-Shen-Jian-Pi-Yi-Qi Therapy Prevents Alcohol-Induced Osteoporosis in Rats.
- Source :
-
American journal of therapeutics [Am J Ther] 2016 Sep-Oct; Vol. 23 (5), pp. e1135-42. - Publication Year :
- 2016
-
Abstract
- Bu-Shen-Jian-Pi-Yi-Qi therapy, which refers to reinforcing kidney, regulating qi, and invigorating spleen, is a traditional Chinese medicine, and we investigated its efficacy in treatment of alcohol-induced osteoporosis and its underlying mechanism. Forty adult male Sprague-Dawley rats were randomly assigned into alcohol-supplemented group, JIAN-GU-LING (JGL) group, calcium D3 + alfacalcidol group, and sham-treated group. Bone mineral density (BMD), bone mineral content (BMC), and bone biomechanical properties were assessed. Biochemical analyses of serum and urine specimens were detected. Reverse transcription-polymerase chain reaction was used to detect the mRNA level of vitamin D receptor (VDR). There were markedly lower bone metabolic markers and biomechanical properties in alcohol-supplemented group compared with sham-treated group (all P < 0.05). BMD, BMC, 25(OH)D3, and 1,25(OH)2D3 were elevated in JGL group relative to calcium D3 + alfacalcidol group (all P < 0.05). U-Ca/Cr and U-P/Cr in JGL group were higher than those in the calcium D3 + alfacalcidol group (all P < 0.05). VDR mRNA level in the JGL group was elevated markedly in comparison with alcohol + calcium D3 + alfacalcidol group (P < 0.05). Based on our results, Bu-Shen-Jian-Pi-Yi-Qi therapy inhibits bone loss, promotes bone formation, and effectively improves bone metabolism in rats with experimental alcoholic osteoporosis. The disease reversal is evidenced by increased BMD and BMC, improved biomechanical properties, elevated VDR mRNA level, enhanced response sensitivity of 1, 25(OH)2D3, and reduced S-Ca/P.
- Subjects :
- Animals
Bone Density drug effects
Calcium administration & dosage
Cholecalciferol administration & dosage
Disease Models, Animal
Ethanol administration & dosage
Hydroxycholecalciferols pharmacology
Male
Osteoporosis etiology
Qi
RNA, Messenger metabolism
Random Allocation
Rats
Rats, Sprague-Dawley
Receptors, Calcitriol genetics
Reverse Transcriptase Polymerase Chain Reaction
Drugs, Chinese Herbal pharmacology
Ethanol adverse effects
Medicine, Chinese Traditional methods
Osteoporosis prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3686
- Volume :
- 23
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 26291589
- Full Text :
- https://doi.org/10.1097/MJT.0000000000000298