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Inherited anomalies of innate immune receptors in pediatric-onset inflammatory diseases.

Authors :
Picard C
Mathieu AL
Hasan U
Henry T
Jamilloux Y
Walzer T
Belot A
Source :
Autoimmunity reviews [Autoimmun Rev] 2015 Dec; Vol. 14 (12), pp. 1147-53. Date of Electronic Publication: 2015 Aug 09.
Publication Year :
2015

Abstract

Pattern-recognition receptors (PRRs) can detect various pathogen-associated molecular patterns such as carbohydrates, nucleic acids or bacterial peptides and play a major role in both innate and adaptive immunity. In physiological conditions, the engagement of PRRs triggers the production of proinflammatory cytokines and promotes pathogen destruction. Inappropriate stimulation or defective regulation of PRR has been recently evidenced in several inherited inflammatory disorders. This new field of childhood-onset inflammatory diseases encompass the so-called type-I interferon-related diseases and autoinflammatory diseases.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1873-0183
Volume :
14
Issue :
12
Database :
MEDLINE
Journal :
Autoimmunity reviews
Publication Type :
Academic Journal
Accession number :
26269221
Full Text :
https://doi.org/10.1016/j.autrev.2015.08.002