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PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?
- Source :
-
Cancer cell [Cancer Cell] 2015 Aug 10; Vol. 28 (2), pp. 143-5. - Publication Year :
- 2015
-
Abstract
- In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequently inactivated in triple-negative breast cancers, functions as a tumor suppressor by specifically modulating the activity of AKT1 in the context of oncogenic PI3K signaling, leading to inhibition of metastatic dissemination.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-3686
- Volume :
- 28
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer cell
- Publication Type :
- Academic Journal
- Accession number :
- 26267528
- Full Text :
- https://doi.org/10.1016/j.ccell.2015.07.010