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ROLE OF RS9939609 FTO GENE VARIANT IN WEIGHT LOSS, INSULIN RESISTANCE AND METABOLIC PARAMETERS AFTER A HIGH MONOUNSATURATED VS A HIGH POLYUNSATURATED FAT HYPOCALORIC DIETS.
- Source :
-
Nutricion hospitalaria [Nutr Hosp] 2015 Jul 01; Vol. 32 (1), pp. 175-81. Date of Electronic Publication: 2015 Jul 01. - Publication Year :
- 2015
-
Abstract
- Introduction: common polymorphisms (rs9939609) of the fat mass and obesity associated gene (FTO) have been linked to obesity.<br />Objectives: our aim was to investigate the role of this polymorphism on insulin resistance, metabolic changes and weight loss secondary to a high monounsaturated fat vs a high polyunsaturated fat hypocaloric diets.<br />Material and Methods: a sample of 233 obese subjects was enrolled in a prospective way. In the basal visit, patients were randomly allocated during 3 months to; Diet M (high monounsaturated fat hypocaloric diet) or Diet P (high polyunsaturated fat hypocaloric diet).<br />Results: after treatment with two diets and in both genotypes, weight, fat mass and waist circumference decreased. Lower levels of body mass index (BMI), weight and fat mass were detected after Diet P in A allele carriers than TT genotype subjects. With the diet type P and in both genotypes (TT and AT + AA), total cholesterol levels (-15.3 + 35.1 mg/dl vs -11.6 + 32.1 mg/dl: p > 0.05) and LDL cholesterol levels (-11.5 + 34.1 mg/dl vs -8.5 + 30.1 mg/dl: p > 0.05) decreased. In A allele carriers a significant decreased was detected in insulin levels (-2.8 + 2.1 UI/L vs -1.3 + 8.0 UI/L: p < 0.05) and HOMA index (-1.0 + 1.3 vs -0.2 + 2.1: p > 0.05), too. With the diet M and in both genotype groups, leptin levels (-8.0 + 17.1 ng/ ml vs -4.9 + 18.7 ng/ml: p > 0.05) decreased. Conclusiones: metabolic improvement secondary to weight loss was better in A carriers with a high polyunsaturated fat hypocaloric diet.<br /> (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)
- Subjects :
- Adult
Alleles
Anthropometry
Biomarkers
Body Weight
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Obesity blood
Obesity genetics
Obesity metabolism
Polymorphism, Single Nucleotide
Alpha-Ketoglutarate-Dependent Dioxygenase FTO genetics
Diet, High-Fat
Energy Metabolism genetics
Genetic Association Studies
Genetic Variation
Insulin Resistance genetics
Weight Loss genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1699-5198
- Volume :
- 32
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nutricion hospitalaria
- Publication Type :
- Academic Journal
- Accession number :
- 26262713
- Full Text :
- https://doi.org/10.3305/nh.2015.32.1.9169