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Enantiomeric Conformation Controls Rate and Yield of Photoinduced Electron Transfer in DNA Sensitized by Ru(II) Dipyridophenazine Complexes.

Enantiomeric Conformation Controls Rate and Yield of Photoinduced Electron Transfer in DNA Sensitized by Ru(II) Dipyridophenazine Complexes.

Authors :
Keane PM
Poynton FE
Hall JP
Clark IP
Sazanovich IV
Towrie M
Gunnlaugsson T
Quinn SJ
Cardin CJ
Kelly JM
Source :
The journal of physical chemistry letters [J Phys Chem Lett] 2015 Feb 19; Vol. 6 (4), pp. 734-8. Date of Electronic Publication: 2015 Feb 09.
Publication Year :
2015

Abstract

Photosensitized oxidation of guanine is an important route to DNA damage. Ruthenium polypyridyls are very useful photosensitizers, as their reactivity and DNA-binding properties are readily tunable. Here we show a strong difference in the reactivity of the two enantiomers of [Ru(TAP)2(dppz)](2+), by using time-resolved visible and IR spectroscopy. This reveals that the photosensitized one-electron oxidation of guanine in three oligonucleotide sequences proceeds with similar rates and yields for bound Δ-[Ru(TAP)2(dppz)](2+), whereas those for the Λ enantiomer are very sensitive to base sequence. It is proposed that these differences are due to preferences of each enantiomer for different binding sites in the duplex.

Details

Language :
English
ISSN :
1948-7185
Volume :
6
Issue :
4
Database :
MEDLINE
Journal :
The journal of physical chemistry letters
Publication Type :
Report
Accession number :
26262495
Full Text :
https://doi.org/10.1021/jz502743q