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Mitotic redistribution of the mitochondrial network by Miro and Cenp-F.
- Source :
-
Nature communications [Nat Commun] 2015 Aug 11; Vol. 6, pp. 8015. Date of Electronic Publication: 2015 Aug 11. - Publication Year :
- 2015
-
Abstract
- Although chromosome partitioning during mitosis is well studied, the molecular mechanisms that allow proper segregation of cytoplasmic organelles in human cells are poorly understood. Here we show that mitochondria interact with growing microtubule tips and are transported towards the daughter cell periphery at the end of mitosis. This phenomenon is promoted by the direct and cell cycle-dependent interaction of the mitochondrial protein Miro and the cytoskeletal-associated protein Cenp-F. Cenp-F is recruited to mitochondria by Miro at the time of cytokinesis and associates with microtubule growing tips. Cells devoid of Cenp-F or Miro show decreased spreading of the mitochondrial network as well as cytokinesis-specific defects in mitochondrial transport towards the cell periphery. Thus, Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells.
- Subjects :
- Amino Acid Sequence
Cell Line, Tumor
Chromosomal Proteins, Non-Histone genetics
Gene Expression Regulation physiology
Humans
Microfilament Proteins genetics
Microtubules physiology
Mitochondrial Proteins genetics
Molecular Sequence Data
Plasmids
rho GTP-Binding Proteins genetics
Chromosomal Proteins, Non-Histone metabolism
Microfilament Proteins metabolism
Mitochondria metabolism
Mitochondrial Proteins metabolism
Mitosis physiology
rho GTP-Binding Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 26259702
- Full Text :
- https://doi.org/10.1038/ncomms9015