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Thymic B Cells and Central T Cell Tolerance.
- Source :
-
Frontiers in immunology [Front Immunol] 2015 Jul 22; Vol. 6, pp. 376. Date of Electronic Publication: 2015 Jul 22 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Central T cell tolerance is believed to be mainly induced by thymic dendritic cells and medullary thymic epithelial cells. The thymus also harbors substantial numbers of B cells. These may arise though intrathymic B lymphopoiesis or immigration from the bloodstream. Importantly, and in contrast to resting "mainstream" B cells in the periphery, thymic B cells display elevated levels of MHC class II and constitutively express CD80. Arguably, their most unexpected feature is the expression of autoimmune regulator. These unique features of thymic B cells result from a licensing process that involves cross-talk with CD4 single-positive T cells and CD40 signaling. Together, these recent findings suggest that B cells play a more prominent role as thymic APCs than previously appreciated.
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26257742
- Full Text :
- https://doi.org/10.3389/fimmu.2015.00376