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Involvement of galanin receptor 2 and CaMKII in galanin-induced antinociception in periaqueductal grey of rats.
- Source :
-
Neuroscience letters [Neurosci Lett] 2015 Sep 14; Vol. 604, pp. 124-7. Date of Electronic Publication: 2015 Aug 05. - Publication Year :
- 2015
-
Abstract
- The present study was performed to explore the effect of the galanin receptor 2 (GalR2) antagonist M871 on the galanin-induced antinociception in periaqueductal grey (PAG), and an involvement of Ca(2+)/calmodulin-dependent kinase II (CaMKII) in the galanin-induced antinociception. Intra-PAG injection of galanin induced marked increases in HWLs to noxious thermal and mechanical stimulation. The increased HWLs to thermal and mechanical stimulation decreased significantly after intra-PAG administration of the GalR2 antagonist M871, indicating an involvement of GalR2 in the galanin-induced antinociception in PAG of rats. Furthermore, rats received intra-PAG injection of galanin, followed 5min later by intra-PAG administration of the CaMKII inhibitor MAP. The galanin-induced increases in HWLs to thermal and mechanical stimulation decreased significantly after intra-PAG administration of MAP, indicating that there is an involvement of CaMKII in the galanin-induced antinociception in PAG, blockade the activity of CaMKII by MAP inhibits the galanin-induced antinociception in PAG of rats. Our results strongly indicate that the galanin-induced antinociception is mediated by GalR2 in the PAG, and CaMKII may be involved in the galanin-induced antinociception in PAG of rats.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Animals
Galanin metabolism
Male
Periaqueductal Gray drug effects
Rats, Sprague-Dawley
Receptor, Galanin, Type 2 antagonists & inhibitors
Analgesics pharmacology
Calcium-Calmodulin-Dependent Protein Kinase Type 2 metabolism
Galanin analogs & derivatives
Galanin pharmacology
Nociception
Peptides pharmacology
Periaqueductal Gray physiology
Receptor, Galanin, Type 2 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7972
- Volume :
- 604
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 26254694
- Full Text :
- https://doi.org/10.1016/j.neulet.2015.08.005