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Rice Bran Protein Hydrolysates Improve Insulin Resistance and Decrease Pro-inflammatory Cytokine Gene Expression in Rats Fed a High Carbohydrate-High Fat Diet.
- Source :
-
Nutrients [Nutrients] 2015 Aug 03; Vol. 7 (8), pp. 6313-29. Date of Electronic Publication: 2015 Aug 03. - Publication Year :
- 2015
-
Abstract
- A high carbohydrate-high fat (HCHF) diet causes insulin resistance (IR) and metabolic syndrome (MS). Rice bran has been demonstrated to have anti-dyslipidemic and anti-atherogenic properties in an obese mouse model. In the present study, we investigated the beneficial effects of rice bran protein hydrolysates (RBP) in HCHF-induced MS rats. After 12 weeks on this diet, the HCHF-fed group was divided into four subgroups, which were orally administered RBP 100 or 500 mg/kg, pioglitazone 10 mg/kg, or tap water for a further 6 weeks. Compared with normal diet control group, the MS rats had elevated levels of blood glucose, lipid, insulin, and HOMA-IR. Treatment with RBP significantly alleviated all those changes and restored insulin sensitivity. Additionally, RBP treatment increased adiponectin and suppressed leptin levels. Expression of Ppar-γ mRNA in adipose tissues was significantly increased whereas expression of lipogenic genes Srebf1 and Fasn was significantly decreased. Levels of mRNA of proinflammatory cytokines, Il-6, Tnf-α, Nos-2 and Mcp-1 were significantly decreased. In conclusion, the present findings support the consumption of RBP as a functional food to improve insulin resistance and to prevent the development of metabolic syndrome.
- Subjects :
- Adipokines blood
Adipose Tissue metabolism
Animals
Cytokines genetics
Dietary Carbohydrates administration & dosage
Dietary Carbohydrates adverse effects
Dietary Fats administration & dosage
Dietary Fats adverse effects
Edible Grain chemistry
Functional Food
Gene Expression drug effects
Inflammation Mediators blood
Insulin blood
Lipogenesis drug effects
Lipogenesis genetics
Male
Metabolic Syndrome blood
Metabolic Syndrome etiology
PPAR gamma genetics
PPAR gamma metabolism
Protein Hydrolysates therapeutic use
Rats, Sprague-Dawley
Cytokines metabolism
Diet adverse effects
Inflammation genetics
Inflammation metabolism
Inflammation prevention & control
Insulin Resistance
Metabolic Syndrome drug therapy
Oryza chemistry
Protein Hydrolysates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 7
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 26247962
- Full Text :
- https://doi.org/10.3390/nu7085292