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Increased Muscle Sympathetic Nerve Activity and Impaired Executive Performance Capacity in Obstructive Sleep Apnea.

Authors :
Goya TT
Silva RF
Guerra RS
Lima MF
Barbosa ER
Cunha PJ
Lobo DM
Buchpiguel CA
Busatto-Filho G
Negrão CE
Lorenzi-Filho G
Ueno-Pardi LM
Source :
Sleep [Sleep] 2016 Jan 01; Vol. 39 (1), pp. 25-33. Date of Electronic Publication: 2016 Jan 01.
Publication Year :
2016

Abstract

Study Objectives: To investigate muscle sympathetic nerve activity (MSNA) response and executive performance during mental stress in obstructive sleep apnea (OSA).<br />Methods: Individuals with no other comorbidities (age = 52 ± 1 y, body mass index = 29 ± 0.4, kg/m2) were divided into two groups: (1) control (n = 15) and (2) untreated OSA (n = 20) defined by polysomnography. Mini-Mental State of Examination (MMSE) and Inteligence quocient (IQ) were assessed. Heart rate (HR), blood pressure (BP), and MSNA (microneurography) were measured at baseline and during 3 min of the Stroop Color Word Test (SCWT). Sustained attention and inhibitory control were assessed by the number of correct answers and errors during SCWT.<br />Results: Control and OSA groups (apnea-hypopnea index, AHI = 8 ± 1 and 47 ± 1 events/h, respectively) were similar in age, MMSE, and IQ. Baseline HR and BP were similar and increased similarly during SCWT in control and OSA groups. In contrast, baseline MSNA was higher in OSA compared to controls. Moreover, MSNA significantly increased in the third minute of SCWT in OSA, but remained unchanged in controls (P < 0.05). The number of correct answers was lower and the number of errors was significantly higher during the second and third minutes of SCWT in the OSA group (P < 0.05). There was a significant correlation (P < 0.01) between the number of errors in the third minute of SCWT with AHI (r = 0.59), arousal index (r = 0.55), and minimum O2 saturation (r = -0.57).<br />Conclusions: As compared to controls, MSNA is increased in patients with OSA at rest, and further significant MSNA increments and worse executive performance are seen during mental stress.<br />Clinical Trial Registration: URL: http://www.clinicaltrials.gov, registration number: NCT002289625.<br /> (© 2016 Associated Professional Sleep Societies, LLC.)

Details

Language :
English
ISSN :
1550-9109
Volume :
39
Issue :
1
Database :
MEDLINE
Journal :
Sleep
Publication Type :
Academic Journal
Accession number :
26237773
Full Text :
https://doi.org/10.5665/sleep.5310