EEG and functional ultrasound imaging in mobile rats.

Authors :: Sieu LA
Bergel A
Tiran E
Deffieux T
Pernot M
Gennisson JL
Tanter M
Cohen I
Source :: Nature methods [Nat Methods] 2015 Sep; Vol. 12 (9), pp. 831-4. Date of Electronic Publication: 2015 Aug 03.
Publication Year :: 2015
Abstract: We developed an integrated experimental framework that extends the brain exploration capabilities of functional ultrasound imaging to awake and mobile rats. In addition to acquiring hemodynamic data, this method further allows parallel access to electroencephalography (EEG) recordings of neuronal activity. We illustrate this approach with two proofs of concept: a behavioral study on theta rhythm activation in a maze running task and a disease-related study on spontaneous epileptic seizures.