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Epididymal Binder of SPerm genes and proteins: what do we know a decade later?
- Source :
-
Andrology [Andrology] 2015 Sep; Vol. 3 (5), pp. 817-24. Date of Electronic Publication: 2015 Jul 31. - Publication Year :
- 2015
-
Abstract
- Binder of SPerm (BSP) proteins from ungulates (more specifically bull, bison, buffalo, stallion, boar, goat, and ram) have been extensively studied in the past 30 years. These proteins secreted by seminal vesicles constitute between 1 and 60% of total seminal plasma proteins depending on the species. In addition to sharing many biochemical characteristics such as the ability to bind to gelatin, glycosaminoglycans, choline phospholipids, and lipoproteins, they also share a main function: promoting sperm capacitation. Over the last 10 years, new members of the BSP superfamily have been discovered. These proteins found in bulls, humans, mice, and rabbits are expressed in the epididymides rather than in seminal vesicles and constitute only a minute percentage of the seminal plasma proteins. However, they share many characteristics with BSPs expressed by accessory glands including their structure, their ability to bind to the aforementioned BSP ligands, as well as their ability to promote sperm capacitation. More investigations need to be done on epididymal BSP proteins, but studies described in this review constitute a solid foundation toward deciphering the significance of epididymal BSP proteins in male fertility.<br /> (© 2015 American Society of Andrology and European Academy of Andrology.)
- Subjects :
- Amino Acid Sequence
Animals
Cattle
Fertility physiology
Gene Expression Regulation
Humans
Male
Mice
Molecular Sequence Data
Protein Binding
Rabbits
Seminal Vesicle Secretory Proteins genetics
Sequence Alignment
Sperm Motility physiology
Spermatozoa metabolism
Epididymis metabolism
Seminal Plasma Proteins metabolism
Seminal Vesicle Secretory Proteins metabolism
Seminal Vesicles metabolism
Sperm Capacitation physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2047-2927
- Volume :
- 3
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Andrology
- Publication Type :
- Academic Journal
- Accession number :
- 26236016
- Full Text :
- https://doi.org/10.1111/andr.12089