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Cystamine/cysteamine rescues the dopaminergic system and shows neurorestorative properties in an animal model of Parkinson's disease.
- Source :
-
Neurobiology of disease [Neurobiol Dis] 2015 Oct; Vol. 82, pp. 430-444. Date of Electronic Publication: 2015 Jul 29. - Publication Year :
- 2015
-
Abstract
- The neuroprotective properties of cystamine identified in pre-clinical studies have fast-tracked this compound to clinical trials in Huntington's disease, showing tolerability and benefits on motor symptoms. We tested whether cystamine could have such properties in a Parkinson's disease murine model and now provide evidence that it can not only prevent the neurodegenerative process but also can reverse motor impairments created by a 6-hydroxydopamine lesion 3 weeks post-surgery. Importantly, we report that cystamine has neurorestorative properties 5 weeks post-lesion as seen on the number of nigral dopaminergic neurons which is comparable with treatments of cysteamine, the reduced form of cystamine used in the clinic, as well as rasagiline, increasingly prescribed in early parkinsonism. All three compounds induced neurite arborization of the remaining dopaminergic cells which was further confirmed in ex vivo dopaminergic explants derived from Pitx3-GFP mice. The disease-modifying effects displayed by cystamine/cysteamine would encourage clinical testing.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Astrocytes drug effects
Astrocytes pathology
Astrocytes physiology
Cell Line
Cells, Cultured
Corpus Striatum drug effects
Corpus Striatum pathology
Corpus Striatum physiopathology
Disease Models, Animal
Dopaminergic Neurons pathology
Dopaminergic Neurons physiology
Indans pharmacology
Lipopolysaccharides
Male
Mice, Inbred C57BL
Neurites drug effects
Neurites pathology
Neurites physiology
Oxidopamine
Parkinsonian Disorders pathology
Parkinsonian Disorders physiopathology
Antiparkinson Agents pharmacology
Cystamine pharmacology
Cysteamine pharmacology
Dopaminergic Neurons drug effects
Neuroprotective Agents pharmacology
Parkinsonian Disorders drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1095-953X
- Volume :
- 82
- Database :
- MEDLINE
- Journal :
- Neurobiology of disease
- Publication Type :
- Academic Journal
- Accession number :
- 26232588
- Full Text :
- https://doi.org/10.1016/j.nbd.2015.07.012