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B-cell receptor signaling in the pathogenesis of lymphoid malignancies.
- Source :
-
Blood cells, molecules & diseases [Blood Cells Mol Dis] 2015 Oct; Vol. 55 (3), pp. 255-65. Date of Electronic Publication: 2015 Jul 11. - Publication Year :
- 2015
-
Abstract
- B-cell receptor (BCR) signaling pathway plays a central role in B-lymphocyte development and initiation of humoral immunity. Recently, BCR signaling pathway has been shown as a major driver in the pathogenesis of B-cell malignancies. As a result, a vast array of BCR-associated kinases has emerged as rational therapeutic targets changing treatment paradigms in B cell malignancies. Based on high efficacy in early-stage clinical trials, there is rapid clinical development of inhibitors targeting BCR signaling pathway. Here, we describe the essential components of BCR signaling, their function in normal and pathogenic signaling and molecular effects of their inhibition in vitro and in vivo.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1096-0961
- Volume :
- 55
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Blood cells, molecules & diseases
- Publication Type :
- Academic Journal
- Accession number :
- 26227856
- Full Text :
- https://doi.org/10.1016/j.bcmd.2015.06.016