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Pleiotropic effects of HDL subfractions and HDL-associated enzymes on protection against coronary artery disease.
- Source :
-
Acta cardiologica [Acta Cardiol] 2015 Jun; Vol. 70 (3), pp. 333-40. - Publication Year :
- 2015
-
Abstract
- Objective: High-density lipoprotein cholesterol (HDL-C) levels are inversely related to the risk of coronary artery disease (CAD). Alterations in HDL-C subclass distribution and HDL-associated enzyme activities may be more important than total HDL levels for the progression of CAD. We intended to investigate the relationship of HDL-C subclass distribution and HDL-associated enzyme activities with CAD.<br />Method and Results: Our study included 101 patients with stable coronary artery disease, and 64 healthy subjects. Serum levels of HDL lipoprotein-associated-phospholipase A2 (HDL-LpPLA2), paraoxonase 1 (PON1), and HDL subfraction distribution were measured. We found increased small HDL (sHDL) subfractions in patients with one-vessel disease (P < 0.001). We also found a reverse correlation between total HDL-C levels and affected vessel number (P < 0.05). Plasma HDL-Lp PLA2 enzyme level was higher in each vessel disease category compared to the control group (P < 0.001). However, PON1 enzyme activity in patients with CAD was not statically significant. Plasma sHDL, HDL-Lp PLA2 enzyme and Lp(a) were significantly different between subjects with CAD and control participants.<br />Conclusions: We demonstrated decreased sHDL particles and a lower cardioprotective HDL-LpPLA, enzyme activity in all patient subgroups compared to controls. Measurement of total HDL-C level only may not be sufficient to predict CAD risk.
Details
- Language :
- English
- ISSN :
- 0001-5385
- Volume :
- 70
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Acta cardiologica
- Publication Type :
- Academic Journal
- Accession number :
- 26226707
- Full Text :
- https://doi.org/10.2143/AC.70.3.3080638