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Phenylthiourea alters toxicity of mercury compounds in zebrafish larvae.
- Source :
-
Journal of inorganic biochemistry [J Inorg Biochem] 2015 Oct; Vol. 151, pp. 10-7. Date of Electronic Publication: 2015 Jul 14. - Publication Year :
- 2015
-
Abstract
- In recent years larval stage zebrafish have been emerging as a standard vertebrate model in a number of fields, ranging from developmental biology to pharmacology and toxicology. The tyrosinase inhibitor 1-phenyl-2-thiourea (PTU) is used very widely with larval zebrafish to generate essentially transparent organisms through inhibition of melanogenesis, which has enabled many elegant studies in areas ranging from neurological development to cancer research. Here we show that PTU can have dramatic synergistic and antagonistic effects on the chemical toxicology of different mercury compounds. Our results indicate that extreme caution should be used when employing PTU in toxicological studies, particularly when studying toxic metal ions.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-3344
- Volume :
- 151
- Database :
- MEDLINE
- Journal :
- Journal of inorganic biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 26226450
- Full Text :
- https://doi.org/10.1016/j.jinorgbio.2015.07.003