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Effects of nicergoline in experimental models related to pathogenesis of migraine.
- Source :
-
Methods and findings in experimental and clinical pharmacology [Methods Find Exp Clin Pharmacol] 1989 Nov; Vol. 11 (11), pp. 671-6. - Publication Year :
- 1989
-
Abstract
- The effect of nicergoline on cerebral blood flow (CBF), cerebrovascular resistance, the constriction of cerebral vessels caused reflectorily or by 5-hydroxytryptamine (5-HT) and on the transport of 5-HT in rat brain synaptosomes was studied using different experimental models. Nicergoline reduced cerebrovascular resistance in the carotid and vertebrobasilar system. The drug decreased carotid blood flow and local cortical CBF, preceded in some experiments by short-lasting CBF increase. Nicergoline almost completely inhibited brain vessels responses in the carotid and vertebrobasilar systems after tibial nerve stimulation. Simultaneously, inhibition of reflectory discharges of the sympathetic nerves was observed. Nicergoline showed an antiserotonin action by antagonizing the 5-HT effect on the cerebral circulation and inhibiting 5-HT-induced constriction of isolated rabbit basilar artery. The inhibition of uptake and enhancement of the release of 5-HT from brain synaptosomes indicates its ability to affect neuronal transmission in serotoninergic neurons. The effects of nicergoline are probably involved in the realization of its antimigraine action.
- Subjects :
- Animals
Basilar Artery drug effects
Cats
Cerebrovascular Circulation drug effects
Disease Models, Animal
In Vitro Techniques
Male
Muscle Contraction drug effects
Muscle, Smooth, Vascular drug effects
Rabbits
Rats
Serotonin metabolism
Synaptosomes drug effects
Synaptosomes metabolism
Vascular Resistance drug effects
Ergolines pharmacology
Migraine Disorders physiopathology
Nicergoline pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0379-0355
- Volume :
- 11
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Methods and findings in experimental and clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 2622296