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Accelerated healing of cutaneous wounds using phytochemically stabilized gold nanoparticle deposited hydrocolloid membranes.
- Source :
-
Biomaterials science [Biomater Sci] 2015 Mar; Vol. 3 (3), pp. 509-19. Date of Electronic Publication: 2015 Jan 02. - Publication Year :
- 2015
-
Abstract
- Rapid healing of dermatological wounds is of vital importance in preventing infection and reducing post-treatment side-effects. Here we report the therapeutic effects of phytochemically stabilized gold nanoparticles (pAuNPs) coated on a hydrocolloid membrane (HCM) for curing cutaneous wounds. Furthermore, the remedial effects of pAuNPs on skin regeneration and angiogenesis were examined using Sprague Dawley® (SD) rats with skin injuries after a pAuNP-deposited hydrocolloid membrane (pAuNP-HCM) had been applied for 15 days. The rate of wound closure was 4 times faster in the pAuNP-HCM-treated group than in the gauze (GZ)- or HCM-treated groups in the first 5 days. Moreover, wound widths in the pAuNP-HCM-treated group were significantly reduced after 5-15 days of treatment following the injury, compared with the other groups. In addition, a significant increase in collagen expression and a decrease in matrix metalloproteinase (MMP)-1 expression and transforming growth factor (TGF-β1) concentration were observed in the pAuNP-HCM-treated group on day 5. Wound tissue applied with the pAuNP-HCM showed enhancement of vascular endothelial growth factor (VEGF), angiopoietin 1 (Ang-1), and angiopoietin 2 (Ang-2) expression. Furthermore, the activity of superoxide dismutases (SODs) was significantly increased in the skin tissue of the pAuNP-HCM-treated group, compared with the GZ- or HCM-treated groups. It is probable that the accelerated process of wound healing in the injured skin of SD rats via pAuNP-HCM results from the synergistic regulation of angiogenesis and connective tissue formation, as well as the stimulation of antioxidant effects.
- Subjects :
- Angiopoietin-2 metabolism
Animals
Bandages, Hydrocolloid
Gold metabolism
Male
Matrix Metalloproteinase 1 metabolism
Phytochemicals
Rats
Rats, Sprague-Dawley
Skin chemistry
Skin pathology
Soft Tissue Injuries
Vascular Endothelial Growth Factor A metabolism
Angiopoietin-2 chemistry
Gold chemistry
Matrix Metalloproteinase 1 chemistry
Metal Nanoparticles chemistry
Skin drug effects
Vascular Endothelial Growth Factor A chemistry
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2047-4849
- Volume :
- 3
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biomaterials science
- Publication Type :
- Academic Journal
- Accession number :
- 26222294
- Full Text :
- https://doi.org/10.1039/c4bm00390j