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Does low serum TSH within the normal range have negative impact on physical exercise capacity and quality of life of healthy elderly people?
- Source :
-
Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2015 Jul 24; Vol. 60 (3), pp. 236-45. - Publication Year :
- 2015
-
Abstract
- Objective: Investigate the differences in cardiopulmonary (CP) capacity and Quality of Life (QOL) between healthy elderly (≥ 65 years) with different TSH levels (< 1.0 and ≥ 1.0 μIU/mL) both within the normal range. Also, evaluate the effects of TSH elevation on CP test and QOL, by administering methimazole to subjects with initial lower-normal TSH, in order to elevate it to superior-normal limit.<br />Materials and Methods: Initially, a cross-sectional study was performed to compare CP capacity at peak exercise and QOL (using WHOQOL-OLD questionnaire) between healthy seniors (age ≥ 65 years) with TSH < 1.0 μIU/mL vs. TSH ≥1.0 μIU/mL. In the second phase, participants with TSH < 1.0 μIU/mL were included in a non-controlled-prospective-interventional study to investigate the effect of TSH elevation, using methimazole, on QOL and CP capacity at peak exercise.<br />Results: From 89 elderly evaluated, 75 had TSH ≥ 1 μIU/mL and 14 TSH < 1 μIU/mL. The two groups had similar basal clinical characteristics. No difference in WHOQOL-OLD scores was observed between groups and they did not differ in terms of CP function at peak exercise. QOL and CP variables were not correlated with TSH levels. Twelve of 14 participants with TSH < 1.0 μIU/mL entered in the prospective study. After one year, no significant differences in clinical caracteristics, QOL, and CP variables were detected in paired analysis before and after methimazole intervention.<br />Conclusions: We found no differences in CP capacity and QOL between health elderly with different TSH levels within normal range and no impact after one year of methimazole treatment. More prospective-controlled-randomized studies are necessary to confirm or not the possible harm effect in normal low TSH.
- Subjects :
- Age Factors
Aged
Aging blood
Cross-Sectional Studies
Exercise Tolerance drug effects
Female
Heart Rate physiology
Humans
Hyperthyroidism blood
Hyperthyroidism physiopathology
Male
Oxygen Consumption drug effects
Oxygen Consumption physiology
Prospective Studies
Reference Values
Statistics, Nonparametric
Surveys and Questionnaires
Thyrotropin drug effects
Thyroxine blood
Antithyroid Agents therapeutic use
Exercise Tolerance physiology
Methimazole therapeutic use
Quality of Life
Thyrotropin blood
Subjects
Details
- Language :
- English
- ISSN :
- 2359-4292
- Volume :
- 60
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives of endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 26222231
- Full Text :
- https://doi.org/10.1590/2359-3997000000079