[MicroRNAs in kidney fibrosis].

Authors :: Van der Hauwaert C
Savary G
Hennino MF
Pottier N
Glowacki F
Cauffiez C
Source :: Nephrologie & therapeutique [Nephrol Ther] 2015 Nov; Vol. 11 (6), pp. 474-82. Date of Electronic Publication: 2015 Jul 26.
Publication Year :: 2015
Abstract: Renal fibrosis represents the final stage of most chronic kidney diseases and contributes to the progressive and irreversible decline in kidney function with accumulation of extracellular matrix components in the renal parenchyma. The molecular mechanisms governing the renal fibrosis process are complex and remain poorly understood. Recently, the profibrotic role of several microRNAs (miRNAs) has been described in kidney fibrosis. MiRNAs are a new class of, small non-coding RNAs of about 20 nucleotides that act as gene expression negative regulators at the post-transcriptional level. Seminal studies have highlighted the potential importance of miRNA as new therapeutic targets and innovative diagnostic and/or prognostic biomarkers. This review summarizes recent scientific advances on the role played by miRNAs in kidney fibrogenesis and discusses potential clinical applications as well as future research directions.<br /> (Copyright © 2015 Association Société de néphrologie. Published by Elsevier SAS. All rights reserved.)