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Covalent bridging of surface functionalized Fe3O4 and YPO4:Eu nanostructures for simultaneous imaging and therapy.
- Source :
-
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2015 Sep 07; Vol. 44 (33), pp. 14686-96. - Publication Year :
- 2015
-
Abstract
- Magnetic luminescent hybrid nanostructures (MLHN) have received a great deal of attention due to their potential biomedical applications such as thermal therapy, magnetic resonance imaging, drug delivery and intracellular imaging. We report the development of bifunctional Fe3O4 decorated YPO4:Eu hybrid nanostructures by covalent bridging of carboxyl PEGylated Fe3O4 and amine functionalized YPO4:Eu particles. The surface functionalization of individual nanoparticulates as well as their successful conjugation was evident from Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), zeta-potential and transmission electron microscopy (TEM) studies. X-ray diffraction (XRD) analysis reveals the formation of highly crystalline hybrid nanostructures. TEM micrographs clearly show the binding/anchoring of 10 nm Fe3O4 nanoparticles onto the surface of 100-150 nm rice grain shaped YPO4:Eu nanostructures. These MLHN show good colloidal stability, magnetic field responsivity and self-heating capacity under an external AC magnetic field. The induction heating studies confirmed localized heating of MLHN under an AC magnetic field with a high specific absorption rate. Photoluminescence spectroscopy and fluorescence microscopy results show optical imaging capability of MLHN. Furthermore, successful internalization of these MLHN in the cells and their cellular imaging ability are confirmed from confocal microscopy imaging. Specifically, the hybrid nanostructure provides an excellent platform to integrate luminescent and magnetic materials into one single entity that can be used as a potential tool for hyperthermia treatment of cancer and cellular imaging.
- Subjects :
- Cell Line, Tumor
Europium therapeutic use
Ferrosoferric Oxide therapeutic use
Humans
Hyperthermia, Induced
Luminescent Agents therapeutic use
Magnetic Fields
Magnetics
Magnetite Nanoparticles chemistry
Magnetite Nanoparticles therapeutic use
Nanostructures therapeutic use
Nanostructures ultrastructure
Neoplasms diagnosis
Neoplasms therapy
Optical Imaging
Yttrium therapeutic use
Europium chemistry
Ferrosoferric Oxide chemistry
Luminescent Agents chemistry
Nanostructures chemistry
Phosphates chemistry
Yttrium chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1477-9234
- Volume :
- 44
- Issue :
- 33
- Database :
- MEDLINE
- Journal :
- Dalton transactions (Cambridge, England : 2003)
- Publication Type :
- Academic Journal
- Accession number :
- 26215789
- Full Text :
- https://doi.org/10.1039/c5dt01522g