Back to Search Start Over

Testicular fine-needle aspiration for the assessment of intratesticular hormone concentrations.

Authors :
Lee AP
Roth MY
Nya-Ngatchou JJ
Lin K
Walsh TJ
Page ST
Matsumoto AM
Bremner WJ
Amory JK
Anawalt BD
Source :
Asian journal of andrology [Asian J Androl] 2016 Jan-Feb; Vol. 18 (1), pp. 21-4.
Publication Year :
2016

Abstract

Measurement of intratesticular sex steroid concentrations in men informs both the development of male hormonal contraceptives and the understanding of male infertility. Given the challenges of using invasive techniques to measure testicular hormone physiology, our group has used a minimally-invasive fine-needle aspiration technique to measure intratesticular hormones in normal healthy men. Herein, we present a post-hoc analysis of the safety and efficacy of testicular fine-needle aspiration (FNA) completed as part of six clinical trials. From 2001 through 2011, a total of 404 procedures were conducted among 163 research volunteers, 85.9% of which were successful in obtaining sufficient fluid for the measurement of intratesticular steroid concentrations. Pain was the most common side effect, with 36.8% of procedures associated with moderate procedural pain and 4.7% with severe procedural pain. Postprocedural pain was uncommon and abated within a few days. Mild local bruising occurred with 14.9% of procedures. Two serious adverse events (0.5%) required surgical intervention. The risk of an adverse event was not associated with age, body mass index, testicular size, or the volume of fluid aspirated. Testicular FNA to obtain fluid for measurement of intratesticular steroid concentrations frequently causes mild to moderate procedural pain, but serious adverse events occur rarely. Testicular FNA has been instrumental for defining human intratesticular hormone physiology and is a minimally-invasive, safe, effective method for obtaining fluid for research on testicular physiology and pathology.

Details

Language :
English
ISSN :
1745-7262
Volume :
18
Issue :
1
Database :
MEDLINE
Journal :
Asian journal of andrology
Publication Type :
Academic Journal
Accession number :
26208394
Full Text :
https://doi.org/10.4103/1008-682X.156637