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[Association between NAT2 polymorphisms with non-syndromic cleft lip with or without cleft palate in Argentina].
- Source :
-
Revista medica de Chile [Rev Med Chil] 2015 Apr; Vol. 143 (4), pp. 444-50. - Publication Year :
- 2015
-
Abstract
- Background: NAT genes are considered candidate genes for the genetic predisposition to non-syndromic Cleft lip with or without cleft palate (NSCLP), since they codify for N-acetyltransferases, enzymes responsible for the biotransformation of arylamines, hydrazine drugs, and a great number of toxins and carcinogens present in diet, cigarette smoke, and environment.<br />Aim: To determine the association between alleles determining slow acetylator phenotype and the risk of NSCLP.<br />Material and Methods: We analyzed *5 (481C>T), *6 (590G>A) and *7 (857G>A) alleles which determine the slow acetylator phenotype and *4 (wild type) allele by polymerase chain reaction/restriction fragment length polymorphism in 97 progenitor-case trios of NSCLP in Argentinian Obstetric Wards. We evaluated the transmission disequilibrium (TDT).<br />Results: TDT showed a positive association between allele *5 and NSCLP (odds ratio = 1,6; p = 0,03).<br />Conclusions: The presence of *5 allele is significantly higher in cases with congenital NSCLP.
- Subjects :
- Alleles
Amplified Fragment Length Polymorphism Analysis
Analysis of Variance
Argentina
Fathers
Female
Genetic Carrier Screening
Genetic Predisposition to Disease
Genotype
Humans
Linkage Disequilibrium
Male
Mothers
Arylamine N-Acetyltransferase genetics
Cleft Lip genetics
Cleft Palate genetics
Polymorphism, Restriction Fragment Length genetics
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0717-6163
- Volume :
- 143
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Revista medica de Chile
- Publication Type :
- Academic Journal
- Accession number :
- 26204535
- Full Text :
- https://doi.org/10.4067/S0034-98872015000400005