A Facile FeCl3/I2-Catalyzed Aerobic Oxidative Coupling Reaction: Synthesis of Tetrasubstituted Imidazoles from Amidines and Chalcones.

Authors :: Zhu Y
Li C
Zhang J
She M
Sun W
Wan K
Wang Y
Yin B
Liu P
Li J
Source :: Organic letters [Org Lett] 2015 Aug 07; Vol. 17 (15), pp. 3872-5. Date of Electronic Publication: 2015 Jul 21.
Publication Year :: 2015
Abstract: A facile and efficient route for the synthesis of tetrasubstituted imidazoles from amidines and chalcones via FeCl3/I2-catalyzed aerobic oxidative coupling has been developed. This new strategy is featured by high regioselectivity and yields, good functional group tolerance, and mild reaction conditions.

Subjects :: Catalysis
Imidazoles chemistry
Molecular Structure
Oxidative Coupling
Amidines chemistry
Chalcones chemistry
Chlorides chemistry
Ferric Compounds chemistry
Imidazoles chemical synthesis
Iodine chemistry

Full Text Access

Tools