B cells in the aging immune system: time to consider B-1 cells.

Authors :: Holodick NE
Rothstein TL
Source :: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2015 Dec; Vol. 1362, pp. 176-87. Date of Electronic Publication: 2015 Jul 20.
Publication Year :: 2015
Abstract: The investigation of immune senescence has uncovered many changes in B cell development, maintenance, and function with increasing age. However, most of these studies have focused on conventional B cell subsets in the spleen. The B-1 cell subset is an essential arm of the innate immune system, which in general has been understudied in terms of immune senescence. Here, we review what is currently known about B cells during aging and go on to describe why B-1 cell biology is an important component of the aging immune system in the context of diseases that most affect the aged population.<br /> (© 2015 New York Academy of Sciences.)