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FH535 inhibited metastasis and growth of pancreatic cancer cells.

Authors :
Wu MY
Liang RR
Chen K
Shen M
Tian YL
Li DM
Duan WM
Gui Q
Gong FR
Lian L
Li W
Tao M
Source :
OncoTargets and therapy [Onco Targets Ther] 2015 Jul 06; Vol. 8, pp. 1651-70. Date of Electronic Publication: 2015 Jul 06 (Print Publication: 2015).
Publication Year :
2015

Abstract

FH535 is a small-molecule inhibitor of the Wnt/β-catenin signaling pathway, which a substantial body of evidence has proven is activated in various cancers, including pancreatic cancer. Activation of the Wnt/β-catenin pathway plays an important role in tumor progression and metastasis. We investigated the inhibitory effect of FH535 on the metastasis and growth of pancreatic cancer cells. Western blotting and luciferase reporter gene assay indicated that FH535 markedly inhibited Wnt/β-catenin pathway viability in pancreatic cancer cells. In vitro wound healing, invasion, and adhesion assays revealed that FH535 significantly inhibited pancreatic cancer cell metastasis. We also observed the inhibitory effect of FH535 on pancreatic cancer cell growth via the tetrazolium and plate clone formation assays. Microarray analyses suggested that changes in the expression of multiple genes could be involved in the anti-cancer effect of FH535 on pancreatic cancer cells. Our results indicate for the first time that FH535 inhibits pancreatic cancer cell metastasis and growth, providing new insight into therapy of pancreatic cancer.

Details

Language :
English
ISSN :
1178-6930
Volume :
8
Database :
MEDLINE
Journal :
OncoTargets and therapy
Publication Type :
Academic Journal
Accession number :
26185454
Full Text :
https://doi.org/10.2147/OTT.S82718