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Copper-Catalyzed Cross-Coupling Reaction of Allyl Boron Ester with 1°/2°/3°-Halogenated Alkanes.

Authors :
Wang GZ
Jiang J
Bu XS
Dai JJ
Xu J
Fu Y
Xu HJ
Source :
Organic letters [Org Lett] 2015 Aug 07; Vol. 17 (15), pp. 3682-5. Date of Electronic Publication: 2015 Jul 16.
Publication Year :
2015

Abstract

The cross-coupling reaction of allyl boron ester with 1°/2°/3°-halogenated alkanes in the presence of copper has been developed for the first time, which provides a mild and efficient method for the construction of saturated C(sp(3))-C(sp(3)) bonds. This protocol shows excellent compatibility with the nonactivated primary, secondary, and even tertiary halogenated alkanes under mild conditions.

Details

Language :
English
ISSN :
1523-7052
Volume :
17
Issue :
15
Database :
MEDLINE
Journal :
Organic letters
Publication Type :
Academic Journal
Accession number :
26181828
Full Text :
https://doi.org/10.1021/acs.orglett.5b01612